Webinar: 3D-BioInfo Webinar- Infrastructure and Functional Annotations
The 3D-BioInfo Community is concerned with improving the ontologies and validation tools for enabling better integration of the data and methods for analysing and predicting protein structures and their complexes. Part of this work is presented in an ongoing series of webinars
Date: Mon 20 Jan 2025 - 16:00 to Mon 20 Jan 2025 - 17:00 GMT
Description
The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and functional contexts. Identifying domains can enable many functional and evolutionary analyses but has remained challenging because of the sheer scale of the data. Using deep learning methods, we have detected and classified every domain in the AFDB, producing The Encyclopedia of Domains. We detected nearly 365 million domains, over 100 million more than can be found by sequence methods, covering more than 1 million taxa. Reassuringly, 77% of the nonredundant domains are similar to known superfamilies, greatly expanding representation of their domain space. We uncovered more than 10,000 new structural interactions between superfamilies and thousands of new folds across the fold space continuum.
Speakers Prof. David Jones (University College London, United Kingdom)